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EGFR-IN-22

CAT: 0804-HY-142679Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-142679Size:1 Each
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Description
EGFR-IN-22 is a potent EGFR inhibitor with IC50s of 4.91 nM and 0.54 nM for wild type EGFR and EGFRL858R/T790M/C797S, respectively (CN112538072A, compound 243) [1].
CAS Number
2634646-14-1
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-22.html
Solubility
10 mM in DMSO
Smiles
O=P(C)(C)C1=C2N=CC=NC2=CC=C1NC3=NC(NC4=C(OC)C=C(N5CCC6(CCN(C(C)(CF)C)CC6)CC5)C(C7=CN(C)N=C7)=C4)=NC=C3Br
Molecular Formula
C38H47BrFN10O2P
Molecular Weight
805.72
References & Citations
EGFRwild type EGFREGFRL858R/T790M/C797SL858R/T790M/C797S[1]
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1

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