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NW-1772

CAT: 0804-HY-14205Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14205Size:1 Each
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Description
NW-1772 (methanesulfonate) (compound 22b) is a potent and selective monoamine oxidase (MAO) B inhibitor. NW-1772 has some advantages, such as rapid blood-brain barrier penetration, short-acting and reversible inhibitory activity, slight inhibition of selected cytochrome P450s, and low in vitro toxicity. NW-1772 can be used for the research of neurodegenerative diseases[1].
CAS Number
911290-35-2
UNSPSC
12352005
Target
Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nw-1772-methanesulfonate.html
Solubility
10 mM in DMSO
Smiles
O=C(C=C1CNC)OC2=C1C=CC(OCC3=CC=CC(Cl)=C3)=C2.CS(=O)(O)=O
Molecular Formula
C19H20ClNO6S
Molecular Weight
425.88
References & Citations
[1]Pisani L, et al. Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[ (3-chlorobenzyl) oxy]-4-[ (methylamino) methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor. J Med Chem. 2009 Nov 12;52 (21) :6685-706.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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