NW 1028

• Description:

  NW 1028 is a potent VCP/p97 inhibitor. NW 1028 targets the ND1L domain of p97 and inhibits the degradation of a p97-dependent reporter. NW 1028 has good binding affinity with Kd values of 100 and 285 nM for ND1L and full length p97, respectively. NW 1028 has the function of regulating the mitotic spindle of cells[1].

• UNSPSC:

  12352005

• Target:

  P97

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nw-1028.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC(NC(N2)=S)=C(C=C1)C2=O)N3[C@H](C(N4[C@H](C(N)=O)CCC4)=O)CCC3

• Molecular Formula:

  C19H21N5O4S

• Molecular Weight:

  415.47

• References & Citations:

  [1]Figuerola-Conchas A, et, al. Small-Molecule Modulators of the ATPase VCP/p97 Affect Specific p97 Cellular Functions. ACS Chem Biol. 2020 Jan 17;15 (1) :243-253.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2749599-78-6]