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NW 1028

CAT: 0804-HY-148122Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-148122Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NW 1028 is a potent VCP/p97 inhibitor. NW 1028 targets the ND1L domain of p97 and inhibits the degradation of a p97-dependent reporter. NW 1028 has good binding affinity with Kd values of 100 and 285 nM for ND1L and full length p97, respectively. NW 1028 has the function of regulating the mitotic spindle of cells[1].
CAS Number
2749599-78-6
UNSPSC
12352005
Target
P97
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nw-1028.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(NC(N2)=S)=C(C=C1)C2=O)N3[C@H](C(N4[C@H](C(N)=O)CCC4)=O)CCC3
Molecular Formula
C19H21N5O4S
Molecular Weight
415.47
References & Citations
[1]Figuerola-Conchas A, et, al. Small-Molecule Modulators of the ATPase VCP/p97 Affect Specific p97 Cellular Functions. ACS Chem Biol. 2020 Jan 17;15 (1) :243-253.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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