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(S, S) -BMS-984923

CAT: 0804-HY-141848ASize: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-141848ASize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(S, S) -BMS-984923 is a less active (S, S) -enantiomer of BMS-984923. (S, S) -BMS-984923 shows an EC50 >1μM for mGluR5 receptor[1]. BMS-984923 is a potent mGluR5 silent allosteric modulator[2]. (S, S) -BMS-984923 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
1375752-77-4
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-s-bms-984923.html
Purity
98.82
Solubility
10 mM in DMSO
Smiles
ClC1=C(C=CC=C1)[C@@]2([H])[C@@](C3=CN=CC(C#CC4=CC=CC=C4)=C3)([H])NC(O2)=O
Molecular Formula
C22H15ClN2O2
Molecular Weight
374.82
References & Citations
[1]Andrew P. Degnan, et al. Oxazolidinones as modulators of mglur5. WO2012064603A1.|[2]Laura T Haas, et al. Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes. Cell Rep. 2017 Jul 5;20 (1) :76-88.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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