MLKL-IN-1

• Description :

  MLKL-IN-1 is a covalent MLKL inhibitor with a KD of 50 μM.

• UNSPSC :

  12352005

• Target :

  Mixed Lineage Kinase

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/mlkl-in-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC(C1=CC=C(N=C([C@@H](OC)C2=CC=C(C(C)C)C=C2)N3)C3=C1)=O

• Molecular Formula :

  C19H20N2O3

• Molecular Weight :

  324.37

• References & Citations :

  [1]Rübbelke M, et al. Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain. J Med Chem. 2021 Nov 11;64 (21) :15629-15638.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2837019-30-2]