MLKL-IN-1

• UNSPSC Description:

  MLKL-IN-1 is a covalent MLKL inhibitor with a KD of 50 μM.

• Target Antigen:

  Mixed Lineage Kinase

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/mlkl-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC(C1=CC=C(N=C([C@@H](OC)C2=CC=C(C(C)C)C=C2)N3)C3=C1)=O

• Molecular Weight:

  324.37

• References & Citations:

  [1]Rübbelke M, et al. Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain. J Med Chem. 2021 Nov 11;64(21):15629-15638.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2837019-30-2