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MLKL-IN-7

CAT: 0804-HY-161361Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161361Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MLKL-IN-7 (compound 9) is a MLKL inhibitor, and shows anti-necroptosis activity in HT-29 cells with the IC50 of 148.4 nM[1].
UNSPSC
12352005
Target
Mixed Lineage Kinase
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mlkl-in-7.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(S(=O)(NC2=NC=C3C=CC=CC3=N2)=O)C=C1)/C=C/C4=CC=C([N+]([O-])=O)S4
Molecular Formula
C21H15N5O5S2
Molecular Weight
481.50
References & Citations
[1]Tang Y, et al. Design, synthesis and anti-necroptosis activity of fused heterocyclic MLKL inhibitors. Bioorg Med Chem. Published online March 1, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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