Products for Research Use Only
RegisterLogin

MLKL-IN-4

CAT: 0804-HY-151542Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-151542Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MLKL-IN-4 (compound 56) is a potent MLKL (Mixed lineage kinase domain-like protein) inhibitor. MLKL-IN-4 inhibits necroptosis in HT-29 cells and acts downstream of MLKL phosphorylation, with EC50 of 82 nM[1]. MLKL-IN-4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
3031406-17-1
UNSPSC
12352005
Target
Mixed Lineage Kinase; Necroptosis; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mlkl-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=C(Cl)N(CC#CC2=CC=C(O)C(CN3C=CC=CC3=O)=C2)C(N(C)C1=O)=O)CCC4=CC=C(C)C=C4
Molecular Formula
C30H27ClN4O5
Molecular Weight
559.01
References & Citations
[1]Cui B, et al. Discovery of a New Class of Uracil Derivatives as Potential Mixed Lineage Kinase Domain-like Protein (MLKL) Inhibitors. J Med Chem. 2022 Oct 13;65 (19) :12747-12780.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-141889-01MLKL-IN-2
HY-151541MLKL-IN-3
HY-156119-01MLKL-IN-6
HY-161361MLKL-IN-7
HY-139878MLKL-IN-1
HY-148767MLKL-IN-5
HY-P702574-01MLKL, Human (His)
HY-156591-01PROTAC MLKL Degrader-1
HY-P80227-01MLKL Antibody (YA289, Rabbit)
HY-169072PROTAC MLKL Degrader-2

Alternative Products

CatalogName
MBS8563429-01MLKL
GTR17695953Phospho-MLKL/MLKL Rabbit Monoclonal Antibody
FNab05217MLKL antibody
BA6509-5.1MLKL-IN-2
T209391-01MLKL-IN-7
T60885-01MLKL-IN-1
AF6903-BPMLKL Peptide
Y401187Anti-MLKL
GTR19212253-01MLKL-IN-5

Popular Products