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MLKL-IN-3

CAT: 0804-HY-151541Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151541Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MLKL-IN-3 (compound 66) is a potent MLKL (Mixed lineage kinase domain-like protein) inhibitor. MLKL-IN-3 inhibits necroptosis in HT-29 cells and acts downstream of MLKL phosphorylation, with EC50 of 31 nM[1]. MLKL-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
3031406-27-3
UNSPSC
12352005
Target
Mixed Lineage Kinase; Necroptosis
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mlkl-in-3.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(C(N(C(N1CC#CC2=CC=C(C(CN3C=CC=C(C3=O)OC)=C2)O)=O)C)=O)NC(CCC4=CC=C(C=C4)C)=O
Molecular Formula
C31H29ClN4O6
Molecular Weight
589.04
References & Citations
[1]Cui B, et al. Discovery of a New Class of Uracil Derivatives as Potential Mixed Lineage Kinase Domain-like Protein (MLKL) Inhibitors. J Med Chem. 2022 Oct 13;65 (19) :12747-12780.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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