MLKL-IN-3

MLKL-IN-3

• CAS Number: 3031406-27-3
• UNSPSC Description: MLKL-IN-3 (compound 66) is a potent MLKL (Mixed lineage kinase domain-like protein) inhibitor. MLKL-IN-3 inhibits necroptosis in HT-29 cells and acts downstream of MLKL phosphorylation, with EC50 of 31 nM[1]. MLKL-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
• Target Antigen: Mixed Lineage Kinase; Necroptosis
• Type: Reference compound
• Related Pathways: Apoptosis;MAPK/ERK Pathway
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/mlkl-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: ClC1=C(C(N(C(N1CC#CC2=CC=C(C(CN3C=CC=C(C3=O)OC)=C2)O)=O)C)=O)NC(CCC4=CC=C(C=C4)C)=O
• Molecular Weight: 589.04
• References & Citations: [1]Cui B, et al. Discovery of a New Class of Uracil Derivatives as Potential Mixed Lineage Kinase Domain-like Protein (MLKL) Inhibitors. J Med Chem. 2022 Oct 13;65(19):12747-12780.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported