BMS-986318

• CAS Number :

  2314378-09-9

• Target :

  FXR|||Others

• Related Pathways :

  Others|||Metabolism

• Bioactivity :

  BMS-986318 is a potent nonbile acid FXR agonist with EC50 values of 53 nM (FXR Gal4) and 350 nM (SRC-1 recruitment assays) . It has a favorable ADME profile and demonstrates effectiveness in mouse models of liver cholestasis and fibrosis caused by bile duct ligation. BMS-986318 is used in research on nonalcoholic steatohepatitis.

• Smiles :

  ClC=1C(C=2C(C=3CC4(C3)CCN(CC4)C5=CC6=C(C=C5)N=C(C(O)=O)C=C6C(F)(F)F)=C(ON2)C7CC7)=C(Cl)C=NC1

• Molecular Formula :

  C30H23Cl2F3N4O3

• Molecular Weight :

  615.43

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C