Indazole 1

• Description:

  Indazole 1 is a potent CDC2-like kinase 2 (CLK2) inhibitor (IC50=12.3 nM) . Indazole 1 inhibits the phosphorylation of SR proteins (e.g., SRSF1, SRSF3) and modulates alternative splicing of Wnt signaling-related genes. Indazole 1 is promising for research of osteoarthritis[1].

• UNSPSC:

  12352005

• Target:

  CDK

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Inflammation/Immunology

• Smiles:

  CC(C)C[C@H](N)COC1=CC(C2=CC3=C(NN=C3C)C=C2)=CN=C1

• Molecular Formula:

  C19H24N4O

• Molecular Weight:

  324.42

• References & Citations:

  [1]Sun Y, et al. Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis. J Med Chem. 2024 Mar 28;67 (6) :4603-4623.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CLK

• CAS Number:

  2252153-37-8