Indazole

• Description:

  Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases[1][2][3][4][5].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  GSK-3; LRRK2; Monoamine Oxidase

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/indazole.html

• Concentration:

  10mM

• Purity:

  99.83

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  C12=CC=CC=C1NN=C2

• Molecular Formula:

  C7H6N2

• Molecular Weight:

  118.14

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Shang C, et al. The Anticancer Activity of Indazole Compounds: A Mini Review. Curr Top Med Chem. 2021;21 (5) :363-376. |[2]Pal D, et al. Importance of Indazole against Neurological Disorders. Curr Top Med Chem. 2022;22 (14) :1136-1151. |[3]Uppulapu SK, et al. Indazole and its Derivatives in Cardiovascular Diseases: Overview, Current Scenario, and Future Perspectives. Curr Top Med Chem. 2022;22 (14) :1177-1188. |[4]Saha S, et al. Indazole Derivatives Effective against Gastrointestinal Diseases. Curr Top Med Chem. 2022;22 (14) :1189-1214. |[5]Qin J, et al. Indazole as a Privileged Scaffold: The Derivatives and their Therapeutic Applications. Anticancer Agents Med Chem. 2021;21 (7) :839-860.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [271-44-3]