OSu-Glu-VC-PAB-MMAD

• UNSPSC Description:

  OSu-Glu-VC-PAB-MMAD is a agent-linker conjugate for ADC with potent antitumor activity by using MMAD (a potent tubulin inhibitor), linked via the cleavable ADC linker OSu-Glu-VC-PAB.

• Target Antigen:

  Drug-Linker Conjugates for ADC; Microtubule/Tubulin

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/osu-glu-vc-pab-mmad.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(CCC1=O)N1OC(CCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N3[C@H]([C@H](OC)[C@@H](C)C(N[C@@H](CC4=CC=CC=C4)C5=NC=CS5)=O)CCC3)=O)=O)=O)=O)C=C2)=O)=O)=O)=O

• Molecular Weight:

  1387.68

• References & Citations:

  [1]Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8(2):114-9.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported