MMAD

• Description :

  MMAD is a potent tubulin inhibitor, is a toxin payload in antibody agent conjugates (ADCs) .

• Product Name Alternative :

  Demethyldolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10

• UNSPSC :

  12352203

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  ADC Payload; Microtubule/Tubulin

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/MMAD.html

• Purity :

  99.94

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C([C@H](C)[C@H]([C@]1([H])CCCN1C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C([C@@H](NC([C@@H](N(C)[H])C(C)C)=O)C(C)C)=O)C)=O)OC)N[C@@H](CC2=CC=CC=C2)C3=NC=CS3

• Molecular Formula :

  C41H66N6O6S

• Molecular Weight :

  771.06

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8 (2) :114-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Auristatin

• CAS Number :

  [203849-91-6]