Dutasteride-13C6

CAT: 0804-HY-13613SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13613SSize:1 mg
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Description
Dutasteride-13C6 is the 13C labeled Dutasteride[1]. Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT[2].
CAS Number
[1217685-27-2]
Product Name Alternative
GG 745-13C6; GI 198745-13C6
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H315, H319
Target
5 alpha Reductase; Apoptosis
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dutasteride-13c6.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@](CC[C@@H]2C(N[13C]3=[13C]([13CH]=[13CH][13C](C(F)(F)F)=[13CH]3)C(F)(F)F)=O)([H])[C@@]4([H])[C@@](CC1)([H])[C@@]5([C@@](NC(C=C5)=O)([H])CC4)C
Molecular Formula
C21 13C6H30F6N2O2
Molecular Weight
534.49
Precautions
H302+H312+H332, H315, H319
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Lazier CB, et al. Dutasteride, the dual 5alpha-reductase inhibitor, inhibits androgen action and promotes cell death in the LNCaP prostate cancer cell line. Prostate. 2004 Feb 1;58 (2) :130-44.|[3]Biancolella M, et al. Effects of dutasteride on the expression of genes related to androgen metabolism and related pathway in human prostate cancer cell lines. Invest New Drugs. 2007 Oct;25 (5) :491-7.|[4]Bramson HN, et al. Unique preclinical characteristics of GG745, a potent dual inhibitor of 5AR. J Pharmacol Exp Ther. 1997 Sep;282 (3) :1496-502.|[5]Andriole GL, et al. Clinical usefulness of serum prostate specific antigen for the detection of prostate cancer is preserved in men receiving the dual 5alpha-reductase inhibitor dutasteride. J Urol. 2006 May;175 (5) :1657-62.|[6]Margiotta-Casaluci L, et al. Mode of action of human pharmaceuticals in fish: the effects of the 5-alpha-reductase inhibitor, dutasteride, on reproduction as a case study. Aquat Toxicol. 2013 Mar 15;128-129:113-23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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