Dutasteride (Standard)

• Description:

  Dutasteride (Standard) is the analytical standard of Dutasteride. This product is intended for research and analytical applications. Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT[1].

• Product Name Alternative:

  GG 745 (Standard) ; GI 198745 (Standard)

• UNSPSC:

  12352005

• Target:

  5 alpha Reductase; Apoptosis; Reference Standards

• Type:

  Reference Standards

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease; Others

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dutasteride-standard.html

• Smiles:

  O=C([C@H]1CC[C@]2([H])[C@]1(C)CC[C@]3([H])[C@@]4(C)C=CC(N[C@]4([H])CC[C@]32[H])=O)NC5=CC(C(F)(F)F)=CC=C5C(F)(F)F

• Molecular Formula:

  C27H30F6N2O2

• Molecular Weight:

  528.53

• References & Citations:

  [1]Lazier CB, et al. Dutasteride, the dual 5alpha-reductase inhibitor, inhibits androgen action and promotes cell death in the LNCaP prostate cancer cell line. Prostate. 2004 Feb 1;58 (2) :130-44.|[2]Biancolella M, et al. Effects of dutasteride on the expression of genes related to androgen metabolism and related pathway in human prostate cancer cell lines. Invest New Drugs. 2007 Oct;25 (5) :491-7.|[3]Bramson HN, et al. Unique preclinical characteristics of GG745, a potent dual inhibitor of 5AR. J Pharmacol Exp Ther. 1997 Sep;282 (3) :1496-502.|[4]Andriole GL, et al. Clinical usefulness of serum prostate specific antigen for the detection of prostate cancer is preserved in men receiving the dual 5alpha-reductase inhibitor dutasteride. J Urol. 2006 May;175 (5) :1657-62.|[5]Margiotta-Casaluci L, et al. Mode of action of human pharmaceuticals in fish: the effects of the 5-alpha-reductase inhibitor, dutasteride, on reproduction as a case study. Aquat Toxicol. 2013 Mar 15;128-129:113-23.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• Clinical Information:

  Launched

• CAS Number:

  [164656-23-9]