Products for Research Use Only
RegisterLogin

Dutasteride-13C,15N, d

CAT: 0804-HY-13613S2Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13613S2Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Dutasteride-13C,15N, d is 15N and deuterated labeled Dutasteride. Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT[1].
Product Name Alternative
GG 745-13C,15N, d; GI 198745-13C,15N, d
UNSPSC
12352005
Target
5 alpha Reductase; Apoptosis; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=[13C]([C@H]1C([2H])C[C@]2([H])[C@]1(C)CC[C@]3([H])[C@@]4(C)C=CC([15NH][C@]4([H])CC[C@]32[H])=O)NC5=CC(C(F)(F)F)=CC=C5C(F)(F)F
Molecular Formula
C26 13CH29DF6N 15NO2
Molecular Weight
531.52
References & Citations
[1]Lazier CB, et al. Dutasteride, the dual 5alpha-reductase inhibitor, inhibits androgen action and promotes cell death in the LNCaP prostate cancer cell line. Prostate. 2004 Feb 1;58 (2) :130-44.|[2]Biancolella M, et al. Effects of dutasteride on the expression of genes related to androgen metabolism and related pathway in human prostate cancer cell lines. Invest New Drugs. 2007 Oct;25 (5) :491-7.|[3]Bramson HN, et al. Unique preclinical characteristics of GG745, a potent dual inhibitor of 5AR. J Pharmacol Exp Ther. 1997 Sep;282 (3) :1496-502.|[4]Andriole GL, et al. Clinical usefulness of serum prostate specific antigen for the detection of prostate cancer is preserved in men receiving the dual 5alpha-reductase inhibitor dutasteride. J Urol. 2006 May;175 (5) :1657-62.|[5]Margiotta-Casaluci L, et al. Mode of action of human pharmaceuticals in fish: the effects of the 5-alpha-reductase inhibitor, dutasteride, on reproduction as a case study. Aquat Toxicol. 2013 Mar 15;128-129:113-23.|[6]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-A0132S8-01N-Acetyl-D-glucosamine-13C,15N
HY-W751750Urethane-13C,15N
HY-Y0842S2-01Formamide-13C,15N
HY-W750551Glyphosate-13C,15N
HY-B0271S1Pyrazinamide-13C,15N
HY-A0132S11-01N-Acetyl-D-glucosamine-13C,15N-1
HY-B1462S2Chlorzoxazone-13C,15N, d2
HY-B0863S5Glyphosate-13C,15N-1
HY-B0451AS6-01Dopamine-13C,15N (hydrochloride)
HY-10019S1Varenicline-15N,13C, d2

Alternative Products

CatalogName
CS-T-102929Urethane-13C,15N
TMIH-0506-01Roxadustat-13C-15N
TRC-G765009-5MGGlyphosate-13C,15N
CS-O-43360Cenobamate - 13C 15N
TRC-P997782-50MGPyrraline-13C,15N
TRC-C685097-5MGConvicine-15N,13C
sc-235213Formamide-13C,15N
AR-A03099-01Azathioprine-13C-15N
CS-CX-00701Bictegravir-13C-D2-15N
sc-497190Ethyl Cyanoformate-13C 15N

Popular Products