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Ataluren-13C6

CAT: 0804-HY-14832S1Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14832S1Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ataluren-13C6 (PTC124-13C6) is 13C labeled Ataluren. Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.
Product Name Alternative
PTC124-13C6
UNSPSC
12352005
Target
Autophagy; CFTR; Isotope-Labeled Compounds
Related Pathways
Autophagy; Membrane Transporter/Ion Channel; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cancer
Smiles
O=C(C1=CC=CC(C2=NOC([13C]3=[13C][13C]=[13C][13C]=[13C]3F)=N2)=C1)O
Molecular Formula
C9 13C6H5FN2O3
Molecular Weight
286.17
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Welch EM, et al. PTC124 targets genetic disorders caused by nonsense mutations. Nature, 2007, 447 (7140), 87-91.|[3]Pettit RS, et al. CFTR Modulators for the Treatment of Cystic Fibrosis. P T. 2014 Jul;39 (7) :500-11.|[4]Miller JN, et al. The novel Cln1 (R151X) mouse model of infantile neuronal ceroid lipofuscinosis (INCL) for testing nonsense suppression therapy. Hum Mol Genet. 2015 Jan 1;24 (1) :185-96.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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