APN-PEG4-DBCO

APN-PEG4-DBCO

• UNSPSC Description: APN-PEG4-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. APN-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
• Target Antigen: ADC Linker
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/apn-peg4-dbco.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(CCC(NCCOCCOCCOCCOCCC(NC1=CC=C(C#CC#N)C=C1)=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4
• Molecular Weight: 676.76
• References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported