Carmustine-d8

• Description :

  Carmustine-d8 is the deuterium labeled Carmustine. Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA[1][2].

• Product Name Alternative :

  BCNU-d8

• UNSPSC :

  12352211

• Target :

  DNA Alkylator/Crosslinker; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Cell Cycle/DNA Damage; Others

• Field of Research :

  Cancer

• Purity :

  98.34

• Solubility :

  H2O : 100 mg/mL (ultrasonic; warming)

• Smiles :

  [2H]C(Cl)(C([2H])(NC(N(C([2H])(C([2H])(Cl)[2H])[2H])N=O)=O)[2H])[2H]

• Molecular Formula :

  C5HD8Cl2N3O2

• Molecular Weight :

  222.10

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Hung CF. Effects of carmustine and lomustine on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adducts in rat glial tumor cells. Neurochem Res. 2000 Jun;25 (6) :845-51.|[3]Demir A, et al. The effect of trimetazidine on intrahepatic cholestasis caused by carmustine in rats. Hepatol Res. 2001 May 1;20 (1) :133-143.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported