VcMMAE-d8

VcMMAE-d8

• UNSPSC Description: VcMMAE-d8 is an isotope of VcMMAE (HY-15575). VcMMAE-d8 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc)[1].
• Target Antigen: Drug-Linker Conjugates for ADC; Microtubule/Tubulin
• Type: Isotope-Labeled Compounds
• Related Pathways: Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Cytoskeleton
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Purity: 97.56
• Solubility: 10 mM in DMSO
• Smiles: CC([C@H](NC(CCCCCN1C(C=CC1=O)=O)=O)C(N[C@H](C(NC2=CC=C(C=C2)COC(N([C@H](C(N[C@@]([2H])(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])C(N([C@H]([C@@H](CC(N3[C@@H](CCC3)[C@@H]([C@H](C(N[C@@H]([C@@H](O)C4=CC=CC=C4)C)=O)C)OC)=O)OC)[C@H](CC)C)C)=O)=O)C(C)C)C)=O)=O)CCCNC(N)=O)=O)C
• Molecular Weight: 1324.68
• References & Citations: [1]Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported