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VcMMAE-d8

CAT: 0804-HY-15575SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15575SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VcMMAE-d8 is an isotope of VcMMAE. VcMMAE-d8 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
Product Name Alternative
MC-Val-Cit-PAB-MMAE-d8; mc-vc-PAB-MMAE-d8
UNSPSC
12352005
Hazard Statement
H300+H330, H340, H360, H370, H372, H412
Target
Drug-Linker Conjugates for ADC; Microtubule/Tubulin
Type
Isotope-Labeled Compounds
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
97.56
Solubility
10 mM in DMSO
Smiles
CC([C@H](NC(CCCCCN1C(C=CC1=O)=O)=O)C(N[C@H](C(NC2=CC=C(C=C2)COC(N([C@H](C(N[C@@]([2H])(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])C(N([C@H]([C@@H](CC(N3[C@@H](CCC3)[C@@H]([C@H](C(N[C@@H]([C@@H](O)C4=CC=CC=C4)C)=O)C)OC)=O)OC)[C@H](CC)C)C)=O)=O)C(C)C)C)=O)=O)CCCNC(N)=O)=O)C
Molecular Formula
C68H97D8N11O15
Molecular Weight
1324.68
Precautions
H300+H330, H340, H360, H370, H372, H412
References & Citations
[1]Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16 (3), 888-897.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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