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Cletoquine-d4

CAT: 0804-HY-135810SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-135810SSize:1 mg
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Description
Cletoquine-d4 is deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV) . Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].
CAS Number
1854126-47-8
Product Name Alternative
Desethylhydroxychloroquine-d4
UNSPSC
12352005
Target
CHIKV; Influenza Virus; Isotope-Labeled Compounds; Parasite
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])(NCCCC(NC1=CC=NC2=CC(Cl)=CC=C12)C)C([2H])(O)[2H]
Molecular Formula
C16H18D4ClN3O
Molecular Weight
311.84
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Charlier B, et al. Development of a novel ion-pairing HPLC-FL method for the separation and quantification of hydroxychloroquine and its metabolites in whole blood. Biomed Chromatogr. 2018 Aug;32 (8) :e4258.|[3]Chhonker YS, et al. Simultaneous quantitation of hydroxychloroquine and its metabolites in mouse blood and tissues using LC-ESI-MS/MS: An application for pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:320-327.|[4]Kumar M, et al. Molecular docking studies of chloroquine and its derivatives against P23pro-zbd domain of chikungunya virus: Implication in designing of novel therapeutic strategies. J Cell Biochem. 2019 Oct;120 (10) :18298-18308.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
Plasmodium

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