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Cletoquine

CAT: 0804-HY-135810Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-135810Size:1 mg
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Description
Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV) . Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].
CAS Number
4298-15-1
Product Name Alternative
Desethylhydroxychloroquine
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
CHIKV; Influenza Virus; Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cletoquine.html
Solubility
10 mM in DMSO
Smiles
CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCNCCO
Molecular Formula
C16H22ClN3O
Molecular Weight
307.82
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Kumar M, et al. Molecular docking studies of chloroquine and its derivatives against P23pro-zbd domain of chikungunya virus: Implication in designing of novel therapeutic strategies. J Cell Biochem. 2019 Oct;120 (10) :18298-18308.|[2]Charlier B, et al. Development of a novel ion-pairing HPLC-FL method for the separation and quantification of hydroxychloroquine and its metabolites in whole blood. Biomed Chromatogr. 2018 Aug;32 (8) :e4258.|[3]Chhonker YS, et al. Simultaneous quantitation of hydroxychloroquine and its metabolites in mouse blood and tissues using LC-ESI-MS/MS: An application for pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:320-327.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium

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