Lomitapide-d4

• Description:

  Lomitapide-d4 (AEGR-733-d4) is deuterium labeled Lomitapide. Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.

• Product Name Alternative:

  AEGR-733-d4; BMS-201038-d4

• UNSPSC:

  12352005

• Target:

  Isotope-Labeled Compounds; Microsomal Triglyceride Transfer Protein (MTP)

• Related Pathways:

  Metabolic Enzyme/Protease; Others

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Smiles:

  O=C(C1=C(C2=CC=C(C=C2)C(F)(F)F)C=CC=C1)NC(CC3)CCN3CC([2H])([2H])C([2H])([2H])CC4(C5=CC=CC=C5C6=CC=CC=C64)C(NCC(F)(F)F)=O

• Molecular Formula:

  C39H33D4F6N3O2

• Molecular Weight:

  697.75

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Sulsky R, et al. 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP. Bioorg Med Chem Lett. 2004 Oct 18;14 (20) :5067-70.|[3]Davis KA. et al. Lomitapide: A novel agent for the treatment of homozygous familial hypercholesterolemia. Am J Health Syst Pharm. 2014 Jun 15;71 (12) :1001-8.|[4]Dhote V, et al. Inhibition of microsomal triglyceride transfer protein improves insulin sensitivity and reduces atherogenic risk in Zucker fatty rats. Clin Exp Pharmacol Physiol. 2011 May;38 (5) :338-44.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [857296-42-5]