ABT-510

• Description:

  ABT-510 is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer. ABT-510 also reduces angiogenesis and inflammatory responses in a murine model of inflammatory bowel disease. ABT-510 can be used in studies of cancer (particularly epithelial ovarian cancer) and inflammatory bowel disease (IBD) [1][2].

• UNSPSC:

  12352209

• Hazard Statement:

  H302-H315-H319

• Target:

  Apoptosis

• Type:

  Peptides

• Related Pathways:

  Apoptosis

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/abt-510.html

• Purity:

  99.87

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  CC(N(C)CC(NCC(N[C@@H](C(C)C)C(N[C@H]([C@@H](C)CC)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(NCC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Formula:

  C46H83N13O11

• Molecular Weight:

  994.23

• Precautions:

  P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

• References & Citations:

  [1]Greenaway J, et al. ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer. Mol Cancer Ther. 2009 Jan;8 (1) :64-74.|[2]Punekar S, et al. Thrombospondin 1 and its mimetic peptide ABT-510 decrease angiogenesis and inflammation in a murine model of inflammatory bowel disease. Pathobiology. 2008;75 (1) :9-21. |[3]Isenberg JS, et.al. Differential effects of ABT-510 and a CD36-binding peptide derived from the type 1 repeats of thrombospondin-1 on fatty acid uptake, nitric oxide signaling, and caspase activation in vascular cells. Biochem Pharmacol. 2008 Feb 15;75 (4) :875-82.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  Phase 2

• CAS Number:

  [251579-55-2]