(E) -C-HDMAPP (ammonium)

• Description:

  (E) -C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E) -HDMAPP. (E) -C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC50=0.91 nM for TNF-α release) [1][2].

• UNSPSC:

  12352211

• Target:

  TNF Receptor

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/e-c-hdmapp-ammonium.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC/C (C) =C/CCP (OP (O) (O) =O) (O) =O.N.N.N

• Molecular Formula:

  C6H23N3O7P2

• Molecular Weight:

  311.21

• References & Citations:

  [1]Boëdec A, et al. Synthesis and biological activity of phosphonate analogues and geometric isomers of the highly potent phosphoantigen (E) -1-hydroxy-2-methylbut-2-enyl 4-diphosphate. J Med Chem. 2008 Mar 27;51 (6) :1747-54.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  TNFRSF1A/CD120a

• CAS Number:

  933030-60-5