(E) -C-HDMAPP (ammonium)

• Description :

  (E) -C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E) -HDMAPP. (E) -C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC50=0.91 nM for TNF-α release) [1][2].

• UNSPSC :

  12352211

• Target :

  TNF Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/e-c-hdmapp-ammonium.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC/C(C)=C/CCP(OP(O)(O)=O)(O)=O.N.N.N

• Molecular Formula :

  C6H23N3O7P2

• Molecular Weight :

  311.21

• References & Citations :

  [1]Boëdec A, et al. Synthesis and biological activity of phosphonate analogues and geometric isomers of the highly potent phosphoantigen (E) -1-hydroxy-2-methylbut-2-enyl 4-diphosphate. J Med Chem. 2008 Mar 27;51 (6) :1747-54.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TNFRSF1A/CD120a

• CAS Number :

  [933030-60-5]