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Maduramicin (ammonium)

CAT: 0804-HY-N7071A-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7071A-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Maduramicin (Maduramycin) ammonium is isolated from the actinomycete Actinomadura rubra. Maduramicin ammonium is an oral active anticoccidial agent used in research related to Eimeria, Adenosarcina, Enterococcus faecalis, and Enterococcus disperitus infections. Maduramicin ammonium induces apoptosis (apoptosis) in chicken cardiomyocytes through both intrinsic and extrinsic pathways and also impairs autophagic flux and induces rhabdomyolysis by activating the AMPK-mediated eIF2α-ATF4 endoplasmic reticulum stress pathway[1][2][3][4].
CAS Number
84878-61-5
Product Name Alternative
Maduramycin (ammonium)
UNSPSC
12352005
Hazard Statement
H301
Target
AMPK; Antibiotic; Apoptosis; Autophagy; Bacterial; Eukaryotic Initiation Factor (eIF)
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/maduramicin-ammonium.html
Purity
99.89
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@]1([C@]2([H])O[C@](C)([C@@]3([H])[C@H](C[C@@]([C@@]4([H])O[C@](O)([C@H](C)C[C@@H]4C)C)([H])O3)O[C@]5([H])C[C@@H]([C@@H](OC)[C@H](C)O5)OC)CC2)O[C@]6(O[C@]([C@H](C)[C@@H](O)C6)([H])[C@H]([C@@]7([H])[C@@H]([C@H]([C@H](C)[C@](CC(O)=O)(O)O7)OC)OC)C)CC1.N
Molecular Formula
C47H83NO17
Molecular Weight
934.16
Precautions
H301
References & Citations
[1]McDougald LR, et al. Efficacy of maduramicin ammonium against coccidiosis in turkeys under laboratory and floor-pen conditions.Avian Dis. 1990 Jul-Sep;34 (3) :634-8.|[2]Gao X, et al.Maduramicin induces apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways.Toxicol In Vitro. 2018 Aug;50:190-200.|[3]Gao X, et al. Ionophore Toxin Maduramicin Produces Haff Disease-Like Rhabdomyolysis in a Mouse Model. Int J Environ Res Public Health. 2020 Oct 27;17 (21) :7882.|[4]Chen X, et al. Maduramicin ammonium impairs autophagic flux through activating AMPK-mediated eIF2α-ATF4 endoplasmic reticulum stress pathway in skeletal muscle. J Sci Food Agric. 2024 Dec 11.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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