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Talotrexin (ammonium)

CAT: 0804-HY-10824BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-10824BSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Talotrexin ammonium is a nonpolyglutamatable antifolate. Talotrexin ammonium improves antitumor activity in a broad spectrum of cancer models by targeting DHFR to inhibit tumor growth[1].
CAS Number
678991-55-4
Product Name Alternative
PT523 (ammonium)
UNSPSC
12352005
Target
Antifolate; Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/talotrexin-ammonium.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(N)=NC2=C1N=C(CNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCCNC(C4=C(C=CC=C4)C(O)=O)=O)=O)C=N2.N.[x]
Molecular Formula
C27H27N9O6.xH3N
References & Citations
[1]C. S. Rocha Lima, et al. A phase I study of talotrexin (PT-523) in patients with relapsed or refractory non-small cell lung cancer (NSCLC) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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