Talotrexin (ammonium)

• UNSPSC Description:

  Talotrexin ammonium is a nonpolyglutamatable antifolate. Talotrexin ammonium improves antitumor activity in a broad spectrum of cancer models by targeting DHFR to inhibit tumor growth[1].

• Target Antigen:

  Antifolate; Dihydrofolate reductase (DHFR)

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/talotrexin-ammonium.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=NC(N)=NC2=C1N=C(CNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCCNC(C4=C(C=CC=C4)C(O)=O)=O)=O)C=N2.N.[x]

• References & Citations:

  [1]C. S. Rocha Lima, et al. A phase I study of talotrexin (PT-523) in patients with relapsed or refractory non-small cell lung cancer (NSCLC).

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 2

• CAS Number:

  678991-55-4