HDMAPP (triammonium)

• Description :

  HDMAPP triammonium is a potent phosphoantigen in the ammonium form and the pyrophosphate form of (E) -HDMAPP. HDMAPP is also a potent activator of γδ T cells and can induce T cell stimulation in vitro (EC50=0.39 nM, TNF-α) [1].

• UNSPSC :

  12352211

• Target :

  TNF Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/hdmapp-triammonium.html

• Purity :

  90.0

• Solubility :

  10 mM in DMSO

• Smiles :

  OC/C(C)=C/COP(OP(O)(O)=O)(O)=O.N.N.N

• Molecular Formula :

  C5H21N3O8P2

• Molecular Weight :

  313.18

• References & Citations :

  [1]Boëdec A, et al. Synthesis and biological activity of phosphonate analogues and geometric isomers of the highly potent phosphoantigen (E) -1-hydroxy-2-methylbut-2-enyl 4-diphosphate. J Med Chem. 2008 Mar 27;51 (6) :1747-54.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TNFRSF1A/CD120a

• CAS Number :

  [443892-56-6]