HDMAPP (triammonium)

• Description:

  HDMAPP triammonium is a potent phosphoantigen in the ammonium form and the pyrophosphate form of (E) -HDMAPP. HDMAPP is also a potent activator of γδ T cells and can induce T cell stimulation in vitro (EC50=0.39 nM, TNF-α) [1].

• UNSPSC:

  12352211

• Target:

  TNF Receptor

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/hdmapp-triammonium.html

• Purity:

  90.0

• Solubility:

  10 mM in DMSO

• Smiles:

  OC/C (C) =C/COP (OP (O) (O) =O) (O) =O.N.N.N

• Molecular Formula:

  C5H21N3O8P2

• Molecular Weight:

  313.18

• References & Citations:

  [1]Boëdec A, et al. Synthesis and biological activity of phosphonate analogues and geometric isomers of the highly potent phosphoantigen (E) -1-hydroxy-2-methylbut-2-enyl 4-diphosphate. J Med Chem. 2008 Mar 27;51 (6) :1747-54.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  TNFRSF1A/CD120a

• CAS Number:

  443892-56-6