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(E) -C-HDMAPP (ammonium salt)

CAT: 0931-T38039-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0931-T38039-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
933030-60-5
Target
Others, TNF
Related Pathways
Others, Apoptosis
Bioactivity
Synthetic and natural alkyl phosphates, also known as phosphoantigens, stimulate the proliferation of γδ-T lymphocytes. Isopentenyl pyrophosphate, and related derivatives including (E) -hydroxy-dimethyl-allyl pyrophosphate ((E) -HDMAPP), are particularly effective activators of γδ-T cells. (E) -C-HDMAPP is the pyrophosphonate form of (E) -HDMAPP. The pyrophosphonate moiety in (E) -C-HDMAPP is much less susceptible to chemical or enzymatic hydrolysis than its pyrophosphate counterpart. As a result, (E) -C-HDMAPP is much more stable in solution and in vascular circulation. (E) -C-HDMAPP possesses comparable activity to (E) -HDMAPP, which is the most potent of the isoprenoid phosphoantigens. (E) -C-HDMAPP stimulates the synthesis of tumor necrosis factor (TNF-α) by γδ-T lymphocytes with an IC50 value of 0.91 nM. (E) -C-HDMAPP also significantly increases the number of circulating γδ-T cells in vivo, in cynomolgus monkeys.
Smiles
OC/C(C)=C/CCP(OP(O)(O)=O)(O)=O.N.N.N
Molecular Formula
C6H23N3O7P2
Molecular Weight
311.21
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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