(E) -C-HDMAPP (ammonium salt)

• Target:

  Others|||TNF

• Related Pathways:

  Others|||Apoptosis

• Bioactivity:

  Synthetic and natural alkyl phosphates, also known as phosphoantigens, stimulate the proliferation of ??-T lymphocytes. Isopentenyl pyrophosphate, and related derivatives including (E) -hydroxy-dimethyl-allyl pyrophosphate ((E) -HDMAPP), are particularly effective activators of ??-T cells. (E) -C-HDMAPP is the pyrophosphonate form of (E) -HDMAPP. The pyrophosphonate moiety in (E) -C-HDMAPP is much less susceptible to chemical or enzymatic hydrolysis than its pyrophosphate counterpart. As a result, (E) -C-HDMAPP is much more stable in solution and in vascular circulation. (E) -C-HDMAPP possesses comparable activity to (E) -HDMAPP, which is the most potent of the isoprenoid phosphoantigens. (E) -C-HDMAPP stimulates the synthesis of tumor necrosis factor (TNF-?) by ??-T lymphocytes with an IC50 value of 0.91 nM. (E) -C-HDMAPP also significantly increases the number of circulating ??-T cells in vivo, in cynomolgus monkeys.

• Smiles:

  OC/C (C) =C/CCP (OP (O) (O) =O) (O) =O.N.N.N

• Molecular Formula:

  C6H23N3O7P2

• Molecular Weight:

  311.21

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  933030-60-5