Lp-PLA2-IN-2

• Description :

  Lp-PLA2-IN-2 is a potent and selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2[1].

• UNSPSC :

  12352005

• Target :

  Phospholipase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/lp-pla2-in-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  N#CC1=CC(OCCN2C(C[C@@H](C(CC3)(C)CCS3(=O)=O)C2)=O)=CC=C1F

• Molecular Formula :

  C19H23FN2O4S

• Molecular Weight :

  394.46

• References & Citations :

  [1]Woolford AJ, et al. Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) . J Med Chem. 2016 Dec 8;59 (23) :10738-10749.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Phospholipase A

• CAS Number :

  [2071636-15-0]