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Ambrisentan (Standard)

CAT: 0804-HY-13209R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13209R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ambrisentan (Standard) is the analytical standard of Ambrisentan. This product is intended for research and analytical applications. Ambrisentan is a selective ET type A receptor (ETAR) antagonist.
CAS Number
177036-94-1
Product Name Alternative
BSF 208075 (Standard) ; LU 208075 (Standard)
UNSPSC
12352005
Hazard Statement
H360
Target
Endothelin Receptor; Reference Standards
Type
Reference Standards
Related Pathways
GPCR/G Protein; Others
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/ambrisentan-standard.html
Smiles
O=C([C@H](C(OC)(C1=CC=CC=C1)C2=CC=CC=C2)OC3=NC(C)=CC(C)=N3)O
Molecular Formula
C22H22N2O4
Molecular Weight
378.42
Precautions
P280-P405-P501
References & Citations
[1]Okamoto T, et al. Antifibrotic effects of Ambrisentan, an endothelin-A receptor antagonist, in a non-alcoholic steatohepatitis mouse model. World J Hepatol. 2016 Aug 8;8 (22) :933-41.|[2]Lisk C, et al. Nrf2 activation: a potential strategy for the prevention of acute mountain sickness. Free Radic Biol Med. 2013 Oct;63:264-73.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Ambrisentan

Ambrisentan is a diarylmethane.

CAS Number177036-94-1
PubChem CID6918493
IUPAC Name(2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid
Molecular FormulaC22H22N2O4
Molecular Weight378.4
XLogP3.8
Topological Polar Surface Area81.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count28
Formal Charge0
Complexity475
SMILES
CC1=CC(=NC(=N1)O[C@H](C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C
InChI
InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1
InChIKey
OUJTZYPIHDYQMC-LJQANCHMSA-N
Chemical Structure
2D Structure
2D structure of Ambrisentan
CAS: 177036-94-1
CID: 6918493
Formula: C22H22N2O4
MW: 378.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight378.4
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass378.15795719
Monoisotopic Mass378.15795719
Topological Polar Surface Area81.5 Ų
Heavy Atom Count28
Formal Charge0
Complexity475
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
TRC-A575860-10MGAmbrisentan

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