Ambrisentan

• Description :

  Ambrisentan is a selective ET type A receptor (ETAR) antagonist.

• CAS Number :

  [177036-94-1]

• Product Name Alternative :

  BSF 208075; LU 208075

• UNSPSC :

  12352005

• Hazard Statement :

  H360

• Target :

  Endothelin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cardiovascular Disease; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/Ambrisentan.html

• Purity :

  99.95

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |Ethanol : 7.14 mg/mL (ultrasonic)

• Smiles :

  O=C([C@H](C(OC)(C1=CC=CC=C1)C2=CC=CC=C2)OC3=NC(C)=CC(C)=N3)O

• Molecular Formula :

  C22H22N2O4

• Molecular Weight :

  378.42

• Precautions :

  H360

• References & Citations :

  [1]Okamoto T, et al. Antifibrotic effects of Ambrisentan, an endothelin-A receptor antagonist, in a non-alcoholic steatohepatitis mouse model. World J Hepatol. 2016 Aug 8;8 (22) :933-41.|[2]Lisk C, et al. Nrf2 activation: a potential strategy for the prevention of acute mountain sickness. Free Radic Biol Med. 2013 Oct;63:264-73.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  ETA