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γ-Acetylenic GABA

CAT: 0804-HY-131693Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-131693Size:1 Each
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Description
γ-Acetylenic GABA (4-Aminohex-5-ynoic acid) is an irreversible inhibitor of GABA-transaminase. γ-Acetylenic GABA can increase the concentration of GABA in rat brain[1][2][3]. γ-Acetylenic GABA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
57659-38-8
Product Name Alternative
GAG
UNSPSC
12352211
Hazard Statement
H315-H319-H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/γ-acetylenic-gaba.html
Solubility
10 mM in DMSO
Smiles
C#CC(N)CCC(O)=O
Molecular Formula
C6H9NO2
Molecular Weight
127.14
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Casey DE, et, al. gamma-Acetylenic GABA in tardive dyskinesia. Arch Gen Psychiatry. 1980 Dec;37 (12) :1376-9. |[2]Palfreyman MG, et, al. The effect of gamma-acetylenic GABA, an enzyme-activated irreversible inhibitor of GABA-transaminase, on dopamine pathways of the extrapyramidal and limbic systems. Eur J Pharmacol. 1978 Aug 15;50 (4) :325-36.|[3]Alabed S, et, al. Gamma-aminobutyric acid agonists for neuroleptic-induced tardive dyskinesia. Cochrane Database Syst Rev. 2011 Apr 13; (4) :CD000203.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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