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3-Methyl-GABA

CAT: 0804-HY-115685-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-115685-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
3-Methyl-GABA is a potent GABA aminotransferase activator. 3-Methyl-GABA can fit the binding pocket of GABAA receptor (GABAaR) . 3-Methyl-GABA can activate L-glutamic acid decarboxylase (GAD) . 3-Methyl-GABA has anticonvulsant activity[1][2].
CAS Number
1216629-00-3
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/3-methyl-gaba.html
Purity
99.86
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=S(C1=C2C=CC=C(S(=O)(O)=O)C2=CC=C1)(O)=O.O=C(O)CC(C)CN.O=C(O)CC(C)CN
Molecular Formula
C20H30N2O10S2
Molecular Weight
522.59
References & Citations
[1]R B Silverman, et al. 3-Alkyl-4-aminobutyric acids: the first class of anticonvulsant agents that activates L-glutamic acid decarboxylase. J Med Chem. 1991 Jul;34 (7) :2295-8.|[2]Z. YANG, et al. MOLECULAR INTERACTIONS OF GABA ANALOGUES AGAINST THE α+β-INTERFACE OF GABAARECEPTOR: DOCKING AND MOLECULAR DYNAMICS STUDIES. Digest Journal of Nanomaterials and Biostructures, Vol. 10, No. 3, July -September 2015.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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