BCN-PEG3-OH

CAT: 0804-HY-130925-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-130925-01Size:5 mg
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Description
BCN-PEG3-OH is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. BCN-PEG3-OH is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
CAS Number
[2126749-77-5]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcn-peg4-oh.html
Purity
99.58
Solubility
10 mM in DMSO
Smiles
[H][C@]12[C@](CCC#CCC2)([H])[C@@H]1COC(NCCOCCOCCOCCO)=O
Molecular Formula
C19H31NO6
Molecular Weight
369.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker

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