BCN-PEG3-OH

• Description :

  BCN-PEG3-OH is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. BCN-PEG3-OH is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• UNSPSC :

  12352203

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  ADC Linker

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/bcn-peg4-oh.html

• Purity :

  99.58

• Solubility :

  10 mM in DMSO

• Smiles :

  [H][C@]12[C@](CCC#CCC2)([H])[C@@H]1COC(NCCOCCOCCOCCO)=O

• Molecular Formula :

  C19H31NO6

• Molecular Weight :

  369.45

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, stored under nitrogen)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Non-cleavable Linker

• CAS Number :

  [2126749-77-5]