BCN-PEG3-OH

• Description:

  BCN-PEG3-OH is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. BCN-PEG3-OH is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• UNSPSC:

  12352203

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  ADC Linker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bcn-peg4-oh.html

• Purity:

  99.58

• Solubility:

  10 mM in DMSO

• Smiles:

  [H][C@]12[C@](CCC#CCC2)([H])[C@@H]1COC(NCCOCCOCCOCCO)=O

• Molecular Formula:

  C19H31NO6

• Molecular Weight:

  369.45

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Non-cleavable Linker

• CAS Number:

  [2126749-77-5]