Mal-PEG2-bis-PEG3-BCN

CAT: 0804-HY-136060-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-136060-01Size:5 mg
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Description
Mal-PEG2-bis-PEG3-BCN is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Mal-PEG2-bis-PEG3-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
CAS Number
[2882973-13-7]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mal-peg2-bis-peg3-bcn.html
Purity
97.33
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[H][C@@]12[C@@](CCC#CCC2)([H])[C@@H]1COC(NCCOCCOCCOCCNC(CCOCC(NC(CCOCCOCCNC(CCN3C(C=CC3=O)=O)=O)=O)COCCC(NCCOCCOCCOCCNC(OC[C@@H]4[C@@]5(CCC#CCC[C@@]54[H])[H])=O)=O)=O)=O
Molecular Formula
C61H95N7O20
Molecular Weight
1246.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker

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