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BCN-PEG3-oxyamine

CAT: 0804-HY-130926Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-130926Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BCN-PEG3-oxyamine is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. BCN-PEG3-oxyamine is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcn-peg3-oxyamine.html
Solubility
10 mM in DMSO
Smiles
[H][C@]12[C@](CCC#CCC2)([H])[C@@H]1COC(NCCOCCOCCOCCNC(CON)=O)=O
Molecular Formula
C21H35N3O7
Molecular Weight
441.52
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker

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