Aminooxy-PEG2-bis-PEG3-BCN

Aminooxy-PEG2-bis-PEG3-BCN

• UNSPSC Description: Aminooxy-PEG2-bis-PEG3-BCN is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG2-bis-PEG3-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
• Target Antigen: ADC Linker
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/aminooxy-peg2-bis-peg3-dbco.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NCCOCCOCCOCCNC(OC[C@@H]1[C@]2(CCC#CCC[C@]21[H])[H])=O)CCOCC(NC(CCOCCOCCON)=O)COCCC(NCCOCCOCCOCCNC(OC[C@@H]3[C@]4(CCC#CCC[C@]43[H])[H])=O)=O
• Molecular Weight: 1111.32
• References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported