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MsbA-IN-6

CAT: 0804-HY-130004Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-130004Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MsbA-IN-6 is a potent inhibitor of MsbA. MsbA-IN-6 is an antibiotic. Gram-negative ATP-binding cassette (ABC) transporter MsbA, an essential inner membrane protein, transports lipopolysaccharide from the inner leaflet to the periplasmic face of the inner membrane. MsbA-IN-6 kills Escherichia coli through inhibition of its ATPase and transport activity, with no loss of activity against clinical multidrug-resistant strains[1][2].
CAS Number
2909443-13-4
UNSPSC
12352005
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/msba-in-6.html
Solubility
10 mM in DMSO
Smiles
C[C@H](OC1=CC2=C(C(/C=C/C3=NNN=N3)=CC=C2C=C1)C4CC4)C5=C(C=CC=C5Cl)Cl
Molecular Formula
C24H20Cl2N4O
Molecular Weight
451.35
References & Citations
[1]Alexander MK, et al. Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA. Antimicrob Agents Chemother. 2018;62 (11) :e01142-18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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