MsbA-IN-3

CAT: 0804-HY-144281Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-144281Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MsbA-IN-3 (compound 31) is a potent and highly selective MsbA inhibitor with an IC50 value of 2 nM. MsbA-IN-3 has inhibitory activity against Escherichia coli with a MIC of 35 μM[1].
CAS Number
[2909443-78-1]
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/msba-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(NS(=O)(C)=O)/C=C/C1=C(C2CC2)C3=CC(O[C@H](C4=C(Cl)C=CC=C4Cl)C)=CC=C3N=C1
Molecular Formula
C24H22Cl2N2O4S
Molecular Weight
505.41
References & Citations
[1]Verma VA, et al. Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity. J Med Chem. 2022;65 (5) :4085-4120.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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