MsbA-IN-4

CAT: 0804-HY-144282Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-144282Size:1 Each
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Description
MsbA-IN-4 (compound 32) is a potent and highly selective MsbA inhibitor with an IC50 value of 3 nM. MsbA-IN-4 has inhibitory activity against Escherichia coli with a MIC of 12 μM[1].
CAS Number
[2909443-80-5]
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/msba-in-4.html
Solubility
10 mM in DMSO
Smiles
C[C@@H](C1=C(Cl)C=CC(F)=C1Cl)OC2=CC=C3N=CC(/C=C/C4=NNN=N4)=C(C5CC5)C3=C2
Molecular Formula
C23H18Cl2FN5O
Molecular Weight
470.33
References & Citations
[1]Verma VA, et al. Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity. J Med Chem. 2022;65 (5) :4085-4120.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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