PD 135158

• Description:

  PD 135158 (CAM 1028) is a selective CCKB receptor antagonist with an IC50 of 2.8 nM against mouse cortex CCKB. PD 135158 shows anxiolytic activity[1].

• Product Name Alternative:

  CAM 1028

• UNSPSC:

  12352005

• Target:

  Cholecystokinin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/pd-135158.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@] (C1 (C) C) (CC[C@@]1 ([H]) C2) [C@@H]2OC (N[C@] (C (NC[C@@H] (C3=CC=CC=C3) NC (CCC (O) =O) =O) =O) (C) CC4=CNC5=CC=CC=C45) =O.O[C@H] ([C@@H] (O) CNC) [C@H] (O) [C@H] (O) CO

• Molecular Formula:

  C42H61N5O11

• Molecular Weight:

  811.96

• References & Citations:

  [1]Hughes J, et al. Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. Proc Natl Acad Sci U S A. 1990 Sep;87 (17) :6728-32.|[2]Gracey DJ, et al. PD-135,158, a cholecystokinin (B) antagonist, enhances latent inhibition in the rat. Pharmacol Biochem Behav. 2000 Mar;65 (3) :459-63.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CCKAR; CCKBR

• CAS Number:

  130325-35-8