PD 135158

• Description :

  PD 135158 (CAM 1028) is a selective CCKB receptor antagonist with an IC50 of 2.8 nM against mouse cortex CCKB. PD 135158 shows anxiolytic activity[1].

• Product Name Alternative :

  CAM 1028

• UNSPSC :

  12352005

• Target :

  Cholecystokinin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/pd-135158.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@](C1(C)C)(CC[C@@]1([H])C2)[C@@H]2OC(N[C@](C(NC[C@@H](C3=CC=CC=C3)NC(CCC(O)=O)=O)=O)(C)CC4=CNC5=CC=CC=C45)=O.O[C@H]([C@@H](O)CNC)[C@H](O)[C@H](O)CO

• Molecular Formula :

  C42H61N5O11

• Molecular Weight :

  811.96

• References & Citations :

  [1]Hughes J, et al. Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. Proc Natl Acad Sci U S A. 1990 Sep;87 (17) :6728-32.|[2]Gracey DJ, et al. PD-135,158, a cholecystokinin (B) antagonist, enhances latent inhibition in the rat. Pharmacol Biochem Behav. 2000 Mar;65 (3) :459-63.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CCKAR; CCKBR

• CAS Number :

  [130325-35-8]