Sulfo-PDBA-DM4

CAT: 0804-HY-128954Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-128954Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Sulfo-PDBA-DM4 is a agent-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Sulfo-PDBA to make antibody agent conjugate (ADC) . Sulfo-PDBA is a gluthatione cleavable linker.
CAS Number
[1461704-01-7]
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sulfo-spdb-linker.html
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCC(C)(C)SSCCC(C(O)=O)S(=O)(O)=O)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)([H])O1
Molecular Formula
C42H60ClN3O15S3
Molecular Weight
978.58
References & Citations
[1]Sun X, et al. Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates. Bioconjug Chem. 2017 May 17;28 (5) :1371-1381.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Maytansinoids

Related Products

CatalogName
HY-101141-01Sulfo-SPDB-DM4
HY-101141RSulfo-SPDB-DM4 (Standard)
HY-150363-01ADC Control Human IgG1-sulfo-SPDB-DM4
HY-12454-01DM4
HY-126494-01DM4-SMCC
HY-128960DBA-DM4
HY-12454S-01DM4-d6
HY-130082-01DM4-SMe
HY-126493DM4-SPDP
HY-12460-01SPDB-DM4

Alternative Products

CatalogName
MBS5771591Sulfo-PDBA-DM4
MBS3845009-01sulfo-SPDB-DM4
A20566-5Sulfo-SPDB-DM4 5mg
A20566-10Sulfo-SPDB-DM4 10mg
A20566-50Sulfo-SPDB-DM4 50mg
A20566-1Sulfo-SPDB-DM4 1mg
BIPG2342-01DM4-S-S-Sulfo-NHS ester
BA2323-10DM4
TRC-S565030-10MGSPDB-DM4
MBS5753026DM4-SMe

Popular Products