DM4-SMe

DM4-SMe

• CAS Number: 796073-68-2
• UNSPSC Description: DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM[1][2].
• Target Antigen: ADC Cytotoxin; Microtubule/Tubulin
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Cytoskeleton
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/dm4-sme.html
• Purity: 98.06
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCC(C)(C)SSC)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1
• Molecular Weight: 826.46
• References & Citations: [1]Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73.|[2]Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported