Products for Research Use Only
RegisterLogin

MRL-871

CAT: 0804-HY-119464-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-119464-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1].
CAS Number
1392809-08-3
Product Name Alternative
(±)-4-Hydroxy Propranolol-d7 (hydrochloride), (±)-4-Hydroxy Propranolol-d17
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mrl-871.html
Purity
99.11
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(C=C1)C2=NN(C3=C2C=CC=C3)C(C4=C(C=CC=C4Cl)C(F)(F)F)=O)O
Molecular Formula
C22H12ClF3N2O3
Molecular Weight
444.79
Precautions
H302, H315, H319, H335
References & Citations
[1]Meijer FA, et, al. Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists. J Med Chem. 2020 Jan 9;63 (1) :241-259.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-135280MRL-650
HY-178129-01MRL-SYKi
HY-120372BMS-871
HY-124598MRL-1237
HY-128773MRL-494
HY-153696MRL-436
HY-122235-01MRL-24
HY-W893040CRBN ligand-871
HY-128773A-01MRL-494 (hydrochloride)
HY-106847SDZ-MRL 953

Alternative Products

CatalogName
BA8324-25MRL-871
T12106-01MRL-494
2764-5MRL-24
GTR19273281-01MRL-SYKi
GTR19264669-01MRL-436
MBS3603846MRL-1237
MBS5814797MRL-494 hydrochloride
GTR19276594-01CRBN ligand-871

Popular Products