KT-333

• Description:

  KT-333 is a molecular glues that degrades STAT3 protein. KT-333 mediates the selective degradation of STAT3 through the ubiquitin-proteasome system by binding to STAT3 protein and E3 ubiquitin ligase von Hippel-Lindau protein (VHL) . KT-333 has strong selectivity for STAT3 protein degradation and good antitumor activity. KT-333 can be used in the study of hematologic malignancies such as large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL) [1].

• UNSPSC:

  12352005

• Target:

  Molecular Glues; STAT

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling; PROTAC; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/kt-333.html

• Purity:

  97.43

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C ([C@H]1N (C ([C@H] (C2) NC (C3=CC4=CC (C ([P] (O) (O) =O) =O) =CC=C4N3) =O) =O) [C@] (CCN2C (C) =O) ([H]) CC1) N[C@@H] (CCC (N) =O) COC (C=CC=C5CCCC (N[C@@H] (C (C) (C) C) C (N (C[C@@H]6O) [C@@H] (C6) C (N[C@H] (C7=CC=C (C (SC=N8) =C8C) C=C7) C) =O) =O) =O) =C5Cl

• Molecular Formula:

  C60H74ClN10O14PS

• Molecular Weight:

  1257.78

• References & Citations:

  [1]Phillip CC Liu, et al. A First-in-Class STAT3 Degrader KT-333 in Development for Treatment of Hematologic Cancers. Blood. Volume 138, Supplement 1, 23 November 2021, Page 1865

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  STAT3

• CAS Number:

  2502186-79-8