KT D606

• UNSPSC Description:

  KT D606 is an inhibitor of the PAK kinase family, with an IC50 value of 4 μM. KT D606 selectively blocks the proliferation of cancer cells transformed by oncogenic RAS mutants and can be used for research on RAS/PAK1-induced cancers[1].

• Target Antigen:

  PAK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/kt-d606.html

• Smiles:

  C[C@]12N3C4=C(C5=CC=CC=C53)C(C(NC6=O)CCCCCCCC7C8=C(C(N7)=O)C9=C%10C%11=C8C%12=CC=CC=C%12N%11[C@](C)([C@](O)(C%13)C(O)=O)O[C@@]%13([H])N%10C%14=CC=CC=C9%14)=C6C%15=C4N([C@](C[C@]2(O)C(O)=O)([H])O1)C%16=CC=CC=C%15%16

• Molecular Weight:

  1003.06

• References & Citations:

  [1]Nheu TV, et al. The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants. Cancer J. 2002 Jul-Aug;8(4):328-36.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1429063-06-8