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AM-8735

CAT: 0804-HY-12734Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12734Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AM-8735 is a potent and selective MDM2 inhibitor with an IC50 of 25 nM.
CAS Number
1429386-01-5
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AM-8735.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@H](CS(=O)(C(C)(C)C)=O)C2CC2)[C@@H](CC(O)=O)O[C@H](C3=CC=CC(Cl)=C3)[C@H]1C4=CC=C(Cl)C=C4
Molecular Formula
C27H31Cl2NO6S
Molecular Weight
568.51
References & Citations
[1]Gonzalez AZ, et al. Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction. J Med Chem. 2014 Mar 27;57 (6) :2472-88.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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