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Mesyl Salvinorin B

CAT: 0804-HY-126910Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-126910Size:500 µg
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Description
Mesyl Salvinorin B is a potent and selective kappa opioid receptor (KOP-r) agonist. Mesyl Salvinorin B prevents the ADE (Alcohol deprivation effect) in mice. Mesyl Salvinorin B dose-dependently reduces alcohol intake and preference in CED (chronic escalation drinking) mice[1][2].
CAS Number
862073-79-8
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/mesyl-salvinorin-b.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H](C[C@H](OS(=O)(C)=O)C([C@@]12[H])=O)[C@]1(C)CC[C@@]([C@]2(C)C[C@@H](C3=COC=C3)O4)([H])C4=O)OC
Molecular Formula
C22H28O9S
Molecular Weight
468.52
References & Citations
[1]Zhou Y, et al. Effects of mesyl salvinorin B alone and in combination with naltrexone on alcohol deprivation effect in male and female mice. Neurosci Lett. 2018 Apr 23;673:19-23.|[2]Zhou Y, et al. Synergistic blockade of alcohol escalation drinking in mice by a combination of novel kappa opioid receptor agonist Mesyl Salvinorin B and naltrexone. Brain Res. 2017 May 1;1662:75-86.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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