Salvinorin B

CAT: 0804-HY-110252-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-110252-01Size:1 mg
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Description
Salvinorin B is a selective and brain-penetrant kappa opioid receptor (KOPr) agonist with an EC50 of 248 nM and Ki of 2.95 μM. Salvinorin B activates downstream signaling pathways by binding to KOPr, inhibits pain transmission and reduces inflammatory response. Salvinorin B can be used for the researches of inflammation, immunology and neurological disease, such as neuropathic pain, multiple sclerosis and anxiety[1][2][3][4][5].
CAS Number
[92545-30-7]
UNSPSC
12352005
Target
Opioid Receptor
Type
Natural Products
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/salvinorin-b.html
Purity
99.90
Solubility
DMSO : 10 mg/mL (ultrasonic; warming)
Smiles
C[C@@]12[C@@]3([C@](CC[C@]1(C(O[C@@H](C2)C4=COC=C4)=O)[H])(C)[C@H](C(OC)=O)C[C@@H](C3=O)O)[H]
Molecular Formula
C21H26O7
Molecular Weight
390.43
References & Citations
[1]Paton KF, et al. The analgesic and anti-inflammatory effects of Salvinorin A analogue β-tetrahydropyran Salvinorin B in mice. Eur J Pain. 2017 Jul;21 (6) :1039-1050.|[2]Paton KF, et al. The Salvinorin Analogue, Ethoxymethyl Ether Salvinorin B, Promotes Remyelination in Preclinical Models of Multiple Sclerosis. Front Neurol. 2021 Dec 20;12:782190.|[3]Moreira CVL, et al. Heteroaromatic salvinorin A analogue (P-3 l) elicits antinociceptive and anxiolytic-like effects. Fitoterapia. 2023 Jun;167:105488.|[4]Kivell BM, et al. Kappa Opioid Receptor Agonist Mesyl Sal B Attenuates Behavioral Sensitization to Cocaine with Fewer Aversive Side-Effects than Salvinorin A in Rodents. Molecules. 2018 Oct 11;23 (10) :2602.|[5]Vardy E, et al. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. 2015 May 20;86 (4) :936-946.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
κ Opioid Receptor/KOR

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